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Spousal network overlap was associated with less depression concordance for husbands; however, for wives, spousal network overlap was directly associated with more depressive symptoms and did not mediate the association with depression concordance.

Our findings suggest that approaches to supporting older adults dealing with mental health disorders may involve support at both the individual and couple levels. Gender-specific strategies could also be devised to improve the mental well-being of the older population.

Our findings suggest that approaches to supporting older adults dealing with mental health disorders may involve support at both the individual and couple levels. Gender-specific strategies could also be devised to improve the mental well-being of the older population.This work is a study on the occurrence of emerging pollutants in the northeast Ecuadorian Amazon. Emerging contaminants (ECs)-caffeine, triclosan, estradiol, acetaminophen, nicotine, and ibuprofen-were quantified by gas chromatography-mass spectrometry in rivers and streams of the Amazon basin near the city of Tena, Ecuador. Folinic For that, a total of 16 natural water samples were taken in 8 locations. Sampling sites included areas impacted by discharges from inefficient sewage networks in urban areas, wastes from fish farming and non-functional landfill, a stream with few threats, tap water, and treated sewage. Caffeine was found in the 38% of the samples studied while trimethoprim and acetaminophen had an occurrence of 13%. Caffeine was detected at two sites receiving untreated sewage and one site receiving treated sewage with mean concentrations that ranged between 19 and 31.5 μg L-1. Acetaminophen (50.4 μg L-1) and trimethoprim (2 μg L-1) were only detected in the river receiving treated sewage effluent. This is the first assessment of emerging contaminants in the upper Ecuadorian Amazon basin, and our observations highlight the need for better sewage treatment and water quality monitoring in Amazonian cities.

The purpose of this study was to analyze medium-to-long-term implant success and survival rates, and lower lip sensory disturbance after placement of dental implants with simultaneous inferior alveolar nerve (IAN) repositioning.

Fifteen patients (3 men, 12 women) treated in two centers were included in this retrospective study. The ages of the participants ranged from 19 to 68. A total of 48 dental implants were placed in 23 posterior mandibular segments simultaneously with IAN transposition or lateralization. The residual bone above the IAN ranged from 0.5 to 7.0 mm. Crestal bone changes were measured using cone beam computed tomography (CBCT) images. Disturbance of the IAN was evaluated subjectively using a modified questionnaire.

The healing process was uneventful in fourteen patients. In one patient, spontaneous fracture of the operated mandible occurred on tenth day after the surgery. The implant in the fracture line was removed at the time of open reduction and fixation. One more implant was lost onjunction with IAN repositioning is an effective and reliable technique. Although neurosensory disturbances are the most common complication after surgery, they tend to resolve over time. Advanced surgical skills are required to perform this technique.Lanthipeptides are a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) characterized by intramolecular thioether cross-links formed between a dehydrated serine/threonine (dSer/dThr) and a cysteine residue. Prochlorosin 2.8 (Pcn2.8) is a class II lanthipeptide that exhibits a non-overlapping thioether ring pattern, for which no biological activity has been reported yet. The variant Pcn2.8 has been shown to bind tightly to the αvβ3 integrin receptor. In the present work, tandem mass spectrometry, using collision-induced dissociation (CID) and electron capture dissociation (ECD), and trapped ion mobility spectrometry-mass spectrometry (TIMS-MS) were used to investigate structural signatures for the non-overlapping thioether ring pattern of Pcn2.8. CID experiments on Pcn2.8 yielded bi and yj fragments between the thioether cross-links, evidencing the presence of a non-overlapping thioether ring pattern. ECD experiments of Pcn2.8 showed a significant increase of hydrogen migration events near the residues involved in the thioether rings with a more pronounced effect at the dehydrated residues as compared to the cysteine residues. The high-resolution mobility analysis, aided by site-directed mutagenesis (, , , , , , and variants), demonstrated that Pcn2.8 adopts cis/trans-conformations at Pro8, Pro11, and Pro12 residues. These observations were complementary to recent NMR findings, for which only the Pro8 residue was evidenced to adopt cis/trans-orientations. This study highlights the analytical power of the TIMS-MS/MS workflow for the structural characterization of lanthipeptides and could be a useful tool in our understanding of the biologically important structural elements that drive the thioether cyclization process.There is evidence that high-frequency transcranial random noise stimulation (hf-tRNS) is effective in improving behavioural performance in several visual tasks. However, so far there has been limited research into the spatial and temporal characteristics of hf-tRNS-induced facilitatory effects. In the present study, electroencephalogram (EEG) was used to investigate the spatial and temporal dynamics of cortical activity modulated by offline hf-tRNS on performance on a motion direction discrimination task. We used EEG to measure the amplitude of motion-related VEPs over the parieto-occipital cortex, as well as oscillatory power spectral density (PSD) at rest. A time-frequency decomposition analysis was also performed to investigate the shift in event-related spectral perturbation (ERSP) in response to the motion stimuli between the pre- and post-stimulation period. The results showed that the accuracy of the motion direction discrimination task was not modulated by offline hf-tRNS. Although the motion task was able to elicit motion-dependent VEP components (P1, N2, and P2), none of them showed any significant change between pre- and post-stimulation. We also found a time-dependent increase of the PSD in alpha and beta bands regardless of the stimulation protocol. Finally, time-frequency analysis showed a modulation of ERSP power in the hf-tRNS condition for gamma activity when compared to pre-stimulation periods and Sham stimulation. Overall, these results show that offline hf-tRNS may induce moderate aftereffects in brain oscillatory activity.

Cognitive impairment occurs in multiple sclerosis (MS) and undergoes a progressive worsening over disease course. However, clinicians still struggle to predict the course of cognitive function. To evaluate baseline clinical and imaging predictors of cognitive abilities worsening over time, we performed a latent trajectory analysis for cognitive performances in MS patients, up to 15years from disease onset.

We collected age, sex, education, dominant and non-dominant 9-hole peg test (9HP) and timed 25-foot walk (T25-FW) as well as MRI measures (grey matter volume and lesion load) within 6months from disease diagnosis for relapsing-remitting MS (RR-MS) patients. At diagnosis and over the follow-up, we also assessed cognitive status through the symbol digit modalities test (SDMT). Cognitive impairment was defined by applying age-, gender- and education-adjusted normative values. Group-based trajectory analysis was performed to determine trajectories, and the predictive value of clinical and imaging variables at baseline was assessed through multinomial logistic regression.

We included 148 RR-MS (98 females and 50 males). Over 11 ± 4year follow-up, 51.4% remained cognitively stable whereas 48.6% cognitively worsened. Cognitively worsening patients had a higher T25FW time (p = 0.004) and a reduced hippocampal volume at baseline (p = 0.04).

Physical disability as well as hippocampal atrophy might depict patients at risk of cognitive worsening over the disease course. Therefore, using such predictors, clinicians may select patients to carefully evaluate for cognitive impairment as to eventually introduce cognitive rehabilitation treatments.

Physical disability as well as hippocampal atrophy might depict patients at risk of cognitive worsening over the disease course. Therefore, using such predictors, clinicians may select patients to carefully evaluate for cognitive impairment as to eventually introduce cognitive rehabilitation treatments.Raymond Garcin, professor of neurology in Paris, France, and his Brazilian assistant, Professor Roberto Melaragno described in 1948 the phenomenon defined as “bégaiement de la mise en route du mouvement” in patients with Parkinson’s disease. This was one of the first descriptions of freezing of gait (FOG) in the world.Watershed land cover affects in-stream water quality and sediment nutrient dynamics. The presence of natural land cover in the riparian zone can reduce the negative effects of agricultural land use on water quality; however, literature evaluating the effects of natural riparian land cover on stream sediment nutrient dynamics is scarce. The objective of this study was to assess if stream sediment phosphorus retention and nitrogen removal varies with riparian forest cover in agricultural watersheds. Stream sediment nutrient dynamics from 28 sites with mixed land cover were sampled three times during the growing season. Phosphorus dynamics and nitrification rates did not change considerably throughout the study period. Sediment total phosphorus concentrations and nitrification rates decreased as riparian forest cover increased likely due to a decline in fine, organic material. Denitrification rates were strongly correlated to surface water nitrate concentrations. Denitrification rate and denitrification enzyme activity decreased with an increase in forest cover during the first sampling period only. The first sampling period coincided with the greatest connectivity between the watershed and in-stream processing, indicating that riparian forest cover indirectly decreased denitrification rates by reducing the concentrations of dissolved nutrients entering the stream. This reduction in load may allow the sediment to maintain greater nitrogen removal efficiency, because bacteria are not saturated with nitrogen. Riparian forest cover also appeared to lessen the effect of agriculture in the watershed by decreasing the amount of fine material in the stream, resulting in reduced phosphorus storage in the stream sediment.This study was conducted to evaluate the effectiveness of best management practices (BMPs) to reduce soil erosion in Gumara watershed of the Abbay (Upper Blue Nile) Basin using the Soil and Water Assessment Tool (SWAT) model. The model was calibrated (1995-2002) and validated (2003-2007) using the SWAT-CUP based on observed streamflow and sediment yield data at the watershed outlet. The study evaluated four individual BMP Scenarios; namely, filter strips (FS), stone/soil bunds (SSB), grassed waterways (GW) and reforestation of croplands (RC), and three blended BMP Scenarios, which combines individual BMPS of FS and RC (FS & RC), GW and RC (GW & RC), and SSB and GW (SSB & GW). Mean annual sediment yield at the baseline conditions was estimated at 19.7 t ha-1yr-1, which was reduced by 13.7, 30.5, 16.2 and 25.9% in the FS, SSB, GW, and RC Scenarios, respectively at the watershed scale. The highest reduction efficiency of 34% was achieved through the implementations of the SSB & GW Scenario. The GW & RC, and FS & RC Scenarios reduced the baseline sediment yield by 32% and 29.